Jessica N. Hosley, 25, and Lee L. Grant, 33, both of Orofino, died at the scene of the landslide near milepost 37 on U.S. Highway 12, just west of Orofino.
Emergency personnel were called to the scene at 7:28 p.m. Thursday night.
Idaho State Police say Grant was driving a Toyota 4-Runner west on Highway 12 when a very large tree fell from the hillside and landed on top of the cab of the vehicle.
Both Hosley and Grant were taken to Pine Hills Funeral Home in Orofino.
No other information about the fatal accident is available at this time.